Mixing Prescription Drugs with Alcohol: Dangers and Effects

If your relationship with alcohol and prescription drugs has reached an unhealthy level, help is available. The Recovery Village offers treatment programs for a wide array of substance use disorders, including alcohol and prescription drugs. These treatment centers, located throughout the United States, provide a full continuum of care for co-occurring disorders like alcohol and drug addiction alongside mental health disorders. Be sure to check on your prescription drugs, as well as your over-the-counter (OTC) medicines, herbals, and dietary supplements like vitamins and minerals.

Although this review is meant to be an overview of alcohol’s interactions with common therapeutic classes, it is not all-inclusive. This review may be used to complement pharmacists’ clinical judgment when providing individualized patient care. This review was conducted through a search of primary and tertiary literature to identify interactions of alcohol with medications in three therapeutic classes (antibiotics, cardiovasculars, and analgesics). Published studies were identified by searching PubMed for various keywords or headings including alcohol, ethanol, drug-alcohol interactions, alcohol and warfarin, and alcohol and hypertension. For the three drug classes, an overview of the available literature is presented and the clinical significance is discussed. The information presented is intended to complement pharmacists’ clinical judgment when providing individualized patient care.

Other Medication Interactions

When combined with alcohol some OTC medicines can have serious drug interactions, too. However, do not stop using any medications without first talking to your doctor. Use of prescription and non-prescription drugs, as well as herbal remedies, also is extremely prevalent.

Prolonged exposure to alcohol means that fats accumulate in the liver, leading to the term ‘fatty liver’. Continued consumption (such as in alcohol use disorder) then leads to cell death in the hepatocytes as the fat stores reduce the function of the cell to the point of death. These cells pills and alcohol effects are then replaced with scar tissue, leading to the condition called cirrhosis. Most countries have passed laws prohibiting driving a motor vehicle while impaired by alcohol. In many jurisdictions, police officers can conduct field tests of suspects to look for signs of intoxication.

Do DayQuil and alcohol mix?

There are many treatment options available, including inpatient rehab, government facilities, counseling and support groups like Alcoholics Anonymous and AI-Anon. Drinking while taking steroids (corticosteroids, or anti-inflammatory medications like prednisone) often used for pain can lead to stomach bleeding and ulcers. NSAIDs like ibuprofen (Advil, Motrin) or naproxen (Aleve) and alcohol use can also cause stomach problems like ulcers. Research has shown that the prevalence of alcohol and medication interactions is widespread.

Prescription opiates (e.g., Vicodin, OxyContin, Tylenol 3 with codeine, Percocet) combined with alcohol can result in slowed or arrested breathing, lowered pulse and blood pressure, unconsciousness, coma, and potential death. Alcohol, like some medicines, can make you sleepy, drowsy, or lightheaded. Small amounts of alcohol can make it dangerous to drive, and when you mix alcohol with certain medicines you put yourself at even greater risk. Combining alcohol with some medicines can lead to falls and serious injuries, especially among older people. Your pharmacist or other health care provider can help you determine which medications interact harmfully with alcohol. Alcohol misuse is dangerous if you have hepatitis B or C and other forms of liver disease because it makes you get sick faster and makes the side effects of your hepatitis treatment worse.

Emerging Trends in Substance Misuse:

The tertiary alcohol tert-amyl alcohol (TAA), also known as 2-methylbutan-2-ol (2M2B), has a history of use as a hypnotic and anesthetic, as do other tertiary alcohols such as methylpentynol, ethchlorvynol, and chloralodol. Metronidazole is an antibacterial agent that kills bacteria by damaging cellular DNA and hence cellular function.[80] Metronidazole is usually given to people who have diarrhea caused by Clostridium difficile bacteria. Patients who are taking metronidazole are sometimes advised to avoid alcohol, even after 1 hour following the last dose. Although older data suggested a possible disulfiram-like effect of metronidazole, newer data has challenged this and suggests it does not actually have this effect. Prolonged heavy consumption of alcohol can cause significant permanent damage to the brain and other organs, resulting in dysfunction or death.

This can lead to a substance use disorder when the drugs are used together, especially in excess. Both alcohol and prescription pain medications cause slowed breathing and impaired motor control. A 2017 study from the American Society of Anesthesiologists found that combining even small amounts of alcohol with prescription oxycodone led to dangerous levels of depressed breathing.

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